No. 21 F/W 22 is a runway show for the brand N21, designed by Alessandro Dell'Acqua. The show took place on February 23, 2022, during Milan Fashion Week F/W 22 Women's. It featured a cast of 39 models, opened by América González and closed by Louise Robert. The casting was directed by Andrea Deanesi, Evelien Joos, and Shaun Beyen.