Luisa Spagnoli F/W 22 is a runway show presented by the brand Luisa Spagnoli. The show took place on February 27, 2022, during Milan Fashion Week F/W 22 Women's. It featured a cast of 23 models, with Vitória Macedo opening the show and Amanda Söderberg closing it. The casting directors for this event were Barbara Nicoli and Leila Ananna.